Apoptotic sensitivity of murine IAP-deficient cells.
نویسندگان
چکیده
Although numerous studies have implicated the IAPs (inhibitor of apoptosis proteins) in the control of apoptotic cell death, analyses of murine Iap-targeted cells have not revealed significant differences in their susceptibility to apoptosis. In the present study, we show that, under defined conditions, murine cells lacking XIAP (X-linked inhibitor of apoptosis) and c-IAP (cellular IAP) 2, but not c-IAP1, exhibit heightened apoptotic sensitivity to both intrinsic and extrinsic apoptotic stimuli.
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عنوان ژورنال:
- The Biochemical journal
دوره 415 1 شماره
صفحات -
تاریخ انتشار 2008